FORM 6-K SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934 November 4, 2005 Commission File Number 001-14978 SMITH & NEPHEW plc (Registrant's name) 15 Adam Street London, England WC2N 6LA (Address of registrant's principal executive offices) [Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.] Form 20-F X Form 40-F --- --- [Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1).] Yes No X --- --- [Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7).] Yes No X --- --- [Indicate by check mark whether by furnishing the information contained in this Form, the registrant is also thereby furnishing information to the Commission pursuant to Rule 12g3-2 (b) under the Securities Exchange Act of 1934.] Yes No X --- --- If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2 (b) : 82- n/a. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. Smith & Nephew plc (Registrant) Date: November 4, 2005 By: /s/ Paul Chambers ----------------- Paul Chambers Company Secretary NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Name of company Smith & Nephew plc 2. Name of shareholder having a major interest The Capital Group Companies, Inc. 3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 Non-beneficial 4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them Capital Guardian Trust Company: State Street Nominees Ltd 82,550 Bank Of New York Nominees Ltd 1,314,743 Northern Trust 71,500 Chase Manhattan Bank Australia Ltd 8,500 Chase Nominees Ltd 6,776,313 BT Globenet Nominees Ltd 137,300 Midland Bank plc 194,900 Cede & Co 119,000 Deutsche Bank Mannheim 4,500 Bankers Trust 9,200 Nortrust Nominees 1,633,140 Royal Bank of Scotland 12,000 MSS Nominees Ltd 31,700 State Street Bank & Trust Co 26,500 RBSTB Nominees Ltd 9,700 Deutsche Bank AG 3,600 HSBC Bank plc 600 ROY Nominees Ltd 6,600 Mellon Nominees (UK) Ltd 388,200 HSBC 5,200 JP Morgan Chase Bank 657,333 Capital International Ltd: State Street Nominees Ltd 38,700 Bank of New York Nominees 909,265 Northern Trust 376,344 Chase Nominees Ltd 658,145 Midland Bank plc 22,900 Bankers Trust 48,100 Citibank London 130,200 Morgan Guaranty 77,500 Nortrust Nominees 803,826 Royal Bank of Scotland 96,400 State Street Bank & Trust Co 69,000 National Westminster Bank 10,800 Deutsche Bank AG 281,041 HSBC Bank plc 265,565 Mellon Bank NA 50,200 KAS UK 8,900 Bank One London 31,300 Capital International SA: Bank of New York Nominees 6,100 Chase Nominees Ltd 83,900 Midland Bank plc 2,400 National Westminster Bank 10,200 Lloyds Bank 5,200 HSBC Bank plc 38,400 Capital Research and Management Company: State Street Nominees Ltd 9,729,000 Chase Nominees Ltd 41,910,620 State Street Bank & Trust Co 118,200 Capital International Inc Nortrust Nominees 23,000 HSBC Bank plc 11,500 5. Number of shares / amount of stock acquired Not disclosed 6. Percentage of issued class Not disclosed 7. Number of shares / amount of stock disposed ............................................................... 8. Percentage of issued class ............................................................... 9. Class of security Ordinary shares of 12 2/9p 10. Date of transaction Not known 11. Date company informed 04.11.05 12. Total holding following this notification 67,309,785 13. Total percentage holding of issued class following this notification 7.17% 14. Any additional information ............................................................... 15. Name of contact and telephone number for queries Phil Higgins - Assistant Company Secretary 020 7960 2228 16. Name and signature of authorised company official responsible for making this notification Phil Higgins - Assistant Company Secretary Date of notification 04.11.05 The FSA does not give any express or implied warranty as to the accuracy of this document or material and does not accept any liability for error or omission. The FSA is not liable for any damages (including, without limitation, damages for loss of business or loss of profits) arising in contract, tort or otherwise from the use of or inability to use this document, or any material contained in it, or from any action or decision taken as a result of using this document or any such material.